Identifying a gene expression signature of frequent COPD exacerbations in peripheral blood using network methods.

ABSTRACT:

Background

Exacerbations of chronic obstructive pulmonary disease (COPD), characterized by acute deterioration in symptoms, may be due to bacterial or viral infections, environmental exposures, or unknown factors. Exacerbation frequency may be a stable trait in COPD patients, which could imply genetic susceptibility. Observing the genes, networks, and pathways that are up- and down-regulated in COPD patients with differing susceptibility to exacerbations will help to elucidate the molecular signature and pathogenesis of COPD exacerbations.

Methods

Gene expression array and plasma biomarker data were obtained using whole-blood samples from subjects enrolled in the Treatment of Emphysema With a Gamma-Selective Retinoid Agonist (TESRA) study. Linear regression, weighted gene co

SUBMITTER: Morrow JD 

PROVIDER: S-EPMC4302028 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature