Evaluation of genetic risk loci for intracranial aneurysms in sporadic arteriovenous malformations of the brain.

ABSTRACT:

Background

In genome-wide association studies (GWAS) five putative risk loci are associated with intracranial aneurysm. As brain arteriovenous malformations (AVM) and intracranial aneurysms are both intracranial vascular diseases and AVMs often have associated aneurysms, we investigated whether these loci are also associated with sporadic brain AVM.

Methods

We included 506 patients (168 Dutch, 338 American) and 1548 controls, all Caucasians. Controls had been recruited as part of previous GWAS. Dutch patients were genotyped by KASPar assay and US patients by Affymetrix SNP 6.0 array. Associations in each cohort were tested by univariable logistic regression modelling, with subgroup analysis in 205 American cases with aneurysm data. Meta-analysis was performed by a Mantel-Hae

SUBMITTER: Kremer PH 

PROVIDER: S-EPMC4302044 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature