Prognostic influence of cyclooxygenase-2 protein and mRNA expression in node-negative breast cancer patients.

ABSTRACT:

Background

Cyclooxygenases (COX) play a key role in prostaglandin metabolism and are important for tumor development and progression. The aim of this study was to analyze the prognostic impact of COX-2 expression in a cohort of lymph node-negative breast cancer patients not treated in the adjuvant setting.

Methods

COX-2 expression was determined by immunohistochemistry (IHC) in tumor tissue of 193 node-negative breast cancer patients. Additionally, mRNA expression was determined in corresponding tumor samples using microarray based gene-expression data. Univariate and multivariate Cox regression analyses adjusted for age at diagnosis, tumor size, histological grade, human epithelial growth factor receptor 2 (HER2), estrogen receptor (ER) and progesterone receptor (PR) were p

SUBMITTER: Sicking I 

PROVIDER: S-EPMC4302078 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature