Role of chromatin and transcriptional co-regulators in mediating p63-genome interactions in keratinocytes.

ABSTRACT:

Background

The Transcription Factor (TF) p63 is a master regulator of epidermal development and differentiation as evident from the remarkable skin phenotype of p63 mouse knockouts. Furthermore, ectopic expression of p63 alone is sufficient to convert simple epithelium into stratified epithelial tissues in vivo and p63 is required for efficient transdifferentiation of fibroblasts into keratinocytes. However, little is known about the molecular mechanisms of p63 function, in particular how it selects its target sites in the genome. p63, which acts both as an activator and repressor of transcription, recognizes a canonical binding motif that occurs over 1 million times in the human genome. But, in human keratinocytes less than 12,000 of these sites are bound in vivo suggesting that u

SUBMITTER: Sethi I 

PROVIDER: S-EPMC4302094 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature