Methodology for the inference of gene function from phenotype data.

ABSTRACT:

Background

Biomedical ontologies are increasingly instrumental in the advancement of biological research primarily through their use to efficiently consolidate large amounts of data into structured, accessible sets. However, ontology development and usage can be hampered by the segregation of knowledge by domain that occurs due to independent development and use of the ontologies. The ability to infer data associated with one ontology to data associated with another ontology would prove useful in expanding information content and scope. We here focus on relating two ontologies: the Gene Ontology (GO), which encodes canonical gene function, and the Mammalian Phenotype Ontology (MP), which describes non-canonical phenotypes, using statistical methods to suggest GO functional annotati

SUBMITTER: Ascensao JA 

PROVIDER: S-EPMC4302099 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature