Is catalytic activity of chaperones a selectable trait for the emergence of heat shock response?

ABSTRACT: Although heat shock response is ubiquitous in bacterial cells, the underlying physical chemistry behind heat shock response remains poorly understood. To study the response of cell populations to heat shock we employ a physics-based ab initio model of living cells where protein biophysics (i.e., folding and protein-protein interactions in crowded cellular environments) and important aspects of proteins homeostasis are coupled with realistic population dynamics simulations. By postulating a genotype-phenotype relationship we define a cell division rate in terms of functional concentrations of proteins and protein complexes, whose Boltzmann stabilities of folding and strengths of their functional interactions are exactly evaluated from their sequence information. We compare and contrast evol

SUBMITTER: Cetinbas M 

PROVIDER: S-EPMC4302207 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature