Duration of androgen suppression before radiotherapy for localized prostate cancer: radiation therapy oncology group randomized clinical trial 9910.

ABSTRACT:

Purpose

To determine whether prolonged androgen suppression (AS) duration before radiotherapy improves survival and disease control in prostate cancer.

Patients and methods

One thousand five hundred seventy-nine men with intermediate-risk prostate cancer were randomly assigned to 8 weeks of AS followed by radiotherapy with an additional 8 weeks of concurrent AS (16 weeks total) or to 28 weeks of AS followed by radiotherapy with an additional 8 weeks of AS (36 weeks total). The trial sought primarily to detect a 33% reduction in the hazard of prostate cancer death in the 28-week assignment. Time-to-event end points are reported for up to 10 years of follow-up.

Results

There were no between-group differences in baseline characteristics of 1,489 eligible patients with fo

SUBMITTER: Pisansky TM 

PROVIDER: S-EPMC4302214 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature