Risk of marrow neoplasms after adjuvant breast cancer therapy: the national comprehensive cancer network experience.

ABSTRACT:

Purpose

Outcomes for early-stage breast cancer have improved. First-generation adjuvant chemotherapy trials reported a 0.27% 8-year cumulative incidence of myelodysplastic syndrome/acute myelogenous leukemia. Incomplete ascertainment and follow-up may have underestimated subsequent risk of treatment-associated marrow neoplasm (MN).

Patients and methods

We examined the MN frequency in 20,063 patients with stage I to III breast cancer treated at US academic centers between 1998 and 2007. Time-to-event analyses were censored at first date of new cancer event, last contact date, or death and considered competing risks. Cumulative incidence, hazard ratios (HRs), and comparisons with Surveillance, Epidemiology, and End Results estimates were obtained. Marrow cytogenetics data were

SUBMITTER: Wolff AC 

PROVIDER: S-EPMC4302215 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature