Collagen type IV at the fetal-maternal interface.

ABSTRACT:

Introduction

Extracellular matrix proteins play a crucial role in influencing the invasion of trophoblast cells. However the role of collagens and collagen type IV (col-IV) in particular at the implantation site is not clear.

Methods

Immunohistochemistry was used to determine the distribution of collagen types I, III, IV and VI in endometrium and decidua during the menstrual cycle and the first trimester of pregnancy. Expression of col-IV alpha chains during the reproductive cycle was determined by qPCR and protein localisation by immunohistochemistry. The structure of col-IV in placenta was examined using transmission electron microscopy. Finally, the expression of col-IV alpha chain NC1 domains and collagen receptors was localised by immunohistochemistry.

Results

Co

SUBMITTER: Oefner CM 

PROVIDER: S-EPMC4302218 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature