Dataset Information

Delta-9-tetrahydrocannabinol, neural oscillations above 20 Hz and induced acute psychosis.

ABSTRACT:

Rationale

An acute challenge with delta-9-tetrahydrocannabinol (THC) can induce psychotic symptoms including delusions. High electroencephalography (EEG) frequencies, above 20 Hz, have previously been implicated in psychosis and schizophrenia.

Objectives

The objective of this study is to determine the effect of intravenous THC compared to placebo on high-frequency EEG.

Methods

A double-blind cross-over study design was used. In the resting state, the high-beta to low-gamma magnitude (21-45 Hz) was investigated (n = 13 pairs + 4 THC only). Also, the event-related synchronisation (ERS) of motor-associated high gamma was studied using a self-paced button press task (n = 15).