Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes.

ABSTRACT:

Objective

Gut microbiome dysbiosis is associated with numerous diseases, including type 1 diabetes. This pilot study determines how geographical location affects the microbiome of infants at high risk for type 1 diabetes in a population of homogenous HLA class II genotypes.

Research design and methods

High-throughput 16S rRNA sequencing was performed on stool samples collected from 90 high-risk, nonautoimmune infants participating in The Environmental Determinants of Diabetes in the Young (TEDDY) study in the U.S., Germany, Sweden, and Finland.

Results

Study site-specific patterns of gut colonization share characteristics across continents. Finland and Colorado have a significantly lower bacterial diversity, while Sweden and Washington state are dominated by Bifidobac

SUBMITTER: Kemppainen KM 

PROVIDER: S-EPMC4302256 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature