Novel metabolic markers for the risk of diabetes development in American Indians.

ABSTRACT:

Objective

To identify novel metabolic markers for diabetes development in American Indians.

Research design and methods

Using an untargeted high-resolution liquid chromatography-mass spectrometry, we conducted metabolomics analysis of study participants who developed incident diabetes (n = 133) and those who did not (n = 298) from 2,117 normoglycemic American Indians followed for an average of 5.5 years in the Strong Heart Family Study. Relative abundances of metabolites were quantified in baseline fasting plasma of all 431 participants. Prospective association of each metabolite with risk of developing type 2 diabetes (T2D) was examined using logistic regression adjusting for established diabetes risk factors.

Results

Seven metabolites (five known and two unknown) si

SUBMITTER: Zhao J 

PROVIDER: S-EPMC4302260 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature