Intraoperative vascular DIVA surgery reveals angiogenic hotspots in tumor zones of malignant gliomas.

ABSTRACT: Malignant gliomas belong to the most threatening tumor entities and are hallmarked by rapid proliferation, hypervascularization and an invasive growth pattern. The primary obstacle in surgical treatment lies in differentiation between healthy and pathological tissue at the tumor margins, where current visualization methods reach their limits. Here, we report on a novel technique (vascular dual intraoperative visualization approach - vDIVA) enabling visualization of different tumor zones (TZ I-III) on the basis of angiogenic hotspots. We investigated glioblastoma patients who underwent 5-ALA fluorescence-guided surgery with simultaneous intraoperative ICG fluorescence angiography. This vDIVA technique revealed hypervascularized areas which were further histologically investigated. Neuropath

SUBMITTER: Eyupoglu IY 

PROVIDER: S-EPMC4302292 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature