Analyzing large-scale samples confirms the association between rs16892766 polymorphism and colorectal cancer susceptibility.

ABSTRACT: Colorectal cancer (CRC) is a common complex disease caused by the combination of genetic variants and environmental factors. Genome-wide association studies (GWAS) have been performed and reported some novel CRC susceptibility variants. The rs16892766 (8q23.3) polymorphism was first identified to be significantly associated with CRC in European ancestry. The following studies investigated this association in Chinese, Japanese, Romanian, Swedish, African American, European American, and Croatian populations. These studies reported consistent and inconsistent results. Here, we reevaluated this association using the relatively large-scale samples from 13 studies (N = 59737, 26237 cases and 33500 controls) using a meta-analysis by searching the PubMed, Google Scholar and CRCgene databases. We

SUBMITTER: Liao M 

PROVIDER: S-EPMC4302297 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature