Correlation between DNA methylation and gene expression in the brains of patients with bipolar disorder and schizophrenia.

ABSTRACT:

Objectives

Aberrant DNA methylation and gene expression have been reported in postmortem brain tissues of psychotic patients, but until now there has been no systematic evaluation of synergistic changes in methylation and expression on a genome-wide scale in brain tissue.

Methods

In this study, genome-wide methylation and expression analyses were performed on cerebellum samples from 39 patients with schizophrenia, 36 patients with bipolar disorder, and 43 unaffected controls, to screen for a correlation between gene expression and CpG methylation.

Results

Out of 71,753 CpG gene pairs (CGPs) tested across the genome, 204 were found to significantly correlate with gene expression after correction for multiple testing [p < 0.05, false discovery rate (FDR) q < 0.05]. The

SUBMITTER: Chen C 

PROVIDER: S-EPMC4302408 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature