Paternal X inactivation does not correlate with X chromosome evolutionary strata in marsupials.

ABSTRACT:

Background

X chromosome inactivation is the transcriptional silencing of one X chromosome in the somatic cells of female mammals. In eutherian mammals (e.g. humans) one of the two X chromosomes is randomly chosen for silencing, with about 15% (usually in younger evolutionary strata of the X chromosome) of genes escaping this silencing. In contrast, in the distantly related marsupial mammals the paternally derived X is silenced, although not as completely as the eutherian X. A chromosome wide examination of X inactivation, using RNA-seq, was recently undertaken in grey short-tailed opossum (Monodelphis domestica) brain and extraembryonic tissues. However, no such study has been conduced in Australian marsupials, which diverged from their American cousins ~80 million years ago, leavi

SUBMITTER: Rodriguez-Delgado CL 

PROVIDER: S-EPMC4302592 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature