Candidate gene-environment interaction research: reflections and recommendations.

ABSTRACT: Studying how genetic predispositions come together with environmental factors to contribute to complex behavioral outcomes has great potential for advancing the understanding of the development of psychopathology. It represents a clear theoretical advance over studying these factors in isolation. However, research at the intersection of multiple fields creates many challenges. We review several reasons why the rapidly expanding candidate gene-environment interaction (cG×E) literature should be considered with a degree of caution. We discuss lessons learned about candidate gene main effects from the evolving genetics literature and how these inform the study of cG×E. We review the importance of the measurement of the gene and environment of interest in cG×E studies. We discuss statistical c

SUBMITTER: Dick DM 

PROVIDER: S-EPMC4302784 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature