A multi-tissue genome-scale metabolic modeling framework for the analysis of whole plant systems.

ABSTRACT: Genome scale metabolic modeling has traditionally been used to explore metabolism of individual cells or tissues. In higher organisms, the metabolism of individual tissues and organs is coordinated for the overall growth and well-being of the organism. Understanding the dependencies and rationale for multicellular metabolism is far from trivial. Here, we have advanced the use of AraGEM (a genome-scale reconstruction of Arabidopsis metabolism) in a multi-tissue context to understand how plants grow utilizing their leaf, stem and root systems across the day-night (diurnal) cycle. Six tissue compartments were created, each with their own distinct set of metabolic capabilities, and hence a reliance on other compartments for support. We used the multi-tissue framework to explore differences in

SUBMITTER: Gomes de Oliveira Dal'Molin C 

PROVIDER: S-EPMC4302846 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature