TGFβ signaling inhibits goblet cell differentiation via SPDEF in conjunctival epithelium.

ABSTRACT: The ocular surface epithelia, including the stratified but non-keratinized corneal, limbal and conjunctival epithelium, in concert with the epidermal keratinized eyelid epithelium, function together to maintain eye health and vision. Abnormalities in cellular proliferation or differentiation in any of these surface epithelia are central in the pathogenesis of many ocular surface disorders. Goblet cells are important secretory cell components of various epithelia, including the conjunctiva; however, mechanisms that regulate goblet cell differentiation in the conjunctiva are not well understood. Herein, we report that conditional deletion of transforming growth factor β receptor II (Tgfbr2) in keratin 14-positive stratified epithelia causes ocular surface epithelial hyperplasia and conjuncti

SUBMITTER: McCauley HA 

PROVIDER: S-EPMC4302933 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature