The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis.

ABSTRACT: Identifying coronary artery progenitors and their developmental pathways could inspire novel regenerative treatments for heart disease. Multiple sources of coronary vessels have been proposed, including the sinus venosus (SV), endocardium and proepicardium, but their relative contributions to the coronary circulation and the molecular mechanisms regulating their development are poorly understood. We created an ApjCreER mouse line as a lineage-tracing tool to map SV-derived vessels onto the heart and compared the resulting lineage pattern with endocardial and proepicardial contributions to the coronary circulation. The data showed a striking compartmentalization to coronary development. ApjCreER-traced vessels contributed to a large number of arteries, capillaries and veins on the dorsal an

SUBMITTER: Chen HI 

PROVIDER: S-EPMC4302936 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature