Revisiting heritability accounting for shared environmental effects and maternal inheritance.

ABSTRACT: Heritability measures the proportion of phenotypic variation attributable to genetic factors. In addition to a shared nuclear genetic component, a number of additional variance components, such as spousal correlation, sibship, household and maternal effects, may have strong contributions to inter-individual phenotype variation. In humans, the confounding effects of these components on heritability have not been studied thoroughly. We sought to obtain unbiased heritability estimates for complex traits in the presence of multiple variance components and also to estimate the contributions of these variance components to complex traits. We compared regression and variance component methods to estimate heritability in simulations when additional variance components existed. We then revisited he

SUBMITTER: Liu C 

PROVIDER: S-EPMC4303043 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature