At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis.

ABSTRACT: The endomembrane system in mammalian cells has evolved over the past two billion years from a simple endocytic pathway in a single-celled primordial ancestor to complex networks supporting multicellular structures that form metazoan tissue and organ systems. The increased organellar complexity of metazoan cells requires additional trafficking machinery absent in yeast or other unicellular organisms to maintain organ homoeostasis and to process the signals that control proliferation, differentiation or the execution of cell death programmes. The PACS (phosphofurin acidic cluster sorting) proteins are one such family of multifunctional membrane traffic regulators that mediate organ homoeostasis and have important roles in diverse pathologies and disease states. This review summarizes our cur

SUBMITTER: Youker RT 

PROVIDER: S-EPMC4303049 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature