Management of respiratory viral infections in hematopoietic cell transplant recipients and patients with hematologic malignancies.

ABSTRACT: Despite preventive strategies and increased awareness, a high incidence of respiratory viral infections still occur in patients with hematologic malignancies (HMs) and in recipients of hematopoietic cell transplant (HCT). Progression of these viral infections to lower respiratory tract may prove fatal, especially in HCT recipients. Increasing evidence on the successful use of ribavirin (alone or in combination with immunomodulators) for the treatment of respiratory syncytial virus infections in HM patients and HCT recipients is available from retrospective studies; however, prospective clinical trials are necessary to establish its efficacy with confidence. The impact on progression to pneumonitis and/or mortality of treating parainfluenza virus infections with available (ribavirin) or inv

SUBMITTER: Chemaly RF 

PROVIDER: S-EPMC4303052 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature