Phylogeny of imported and reestablished wild polioviruses in theDemocratic Republic of the Congo from 2006 to 2011.

ABSTRACT:

Background

The last case of polio associated with wild poliovirus (WPV) indigenous to the Democratic Republic of the Congo (DRC) was reported in 2001, marking a major milestone toward polio eradication in Africa. However, during 2006-2011, outbreaks associated with WPV type 1 (WPV1) were widespread in the DRC, with >250 reported cases.

Methods

WPV1 isolates obtained from patients with acute flaccid paralysis (AFP) were compared by nucleotide sequencing of the VP1 capsid region (906 nucleotides). VP1 sequence relationships among isolates from the DRC and other countries were visualized in phylogenetic trees, and isolates representing distinct lineage groups were mapped.

Results

Phylogenetic analysis indicated that WPV1 was imported twice in 2004-2005 and once in approx

SUBMITTER: Gumede N 

PROVIDER: S-EPMC4303083 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature