A novel role for ezrin in breast cancer angio/lymphangiogenesis.

ABSTRACT:

Introduction

Recent evidence suggests that tumour lymphangiogenesis promotes lymph node metastasis, a major prognostic factor for survival of breast cancer patients. However, signaling mechanisms involved in tumour-induced lymphangiogenesis remain poorly understood. The expression of ezrin, a membrane cytoskeletal crosslinker and Src substrate, correlates with poor outcome in a diversity of cancers including breast. Furthermore, ezrin is essential in experimental invasion and metastasis models of breast cancer. Ezrin acts cooperatively with Src in the regulation of the Src-induced malignant phenotype and metastasis. However, it remains unclear if ezrin plays a role in Src-induced tumour angio/lymphangiogenesis.

Methods

The effects of ezrin knockdown and mutation on angio/lym

SUBMITTER: Ghaffari A 

PROVIDER: S-EPMC4303119 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature