Identification of chemokine receptors as potential modulators of endocrine resistance in oestrogen receptor-positive breast cancers.

ABSTRACT:

Introduction

Endocrine therapies target oestrogenic stimulation of breast cancer (BC) growth, but resistance remains problematic. Our aims in this study were (1) to identify genes most strongly associated with resistance to endocrine therapy by intersecting global gene transcription data from patients treated presurgically with the aromatase inhibitor anastrazole with those from MCF7 cells adapted to long-term oestrogen deprivation (LTED) (2) to assess the clinical value of selected genes in public clinical data sets and (3) to determine the impact of targeting these genes with novel agents.

Methods

Gene expression and Ki67 data were available from 69 postmenopausal women with oestrogen receptor-positive (ER+) early BC, at baseline and 2 weeks after anastrazole treatment, an

SUBMITTER: Ribas R 

PROVIDER: S-EPMC4303127 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature