Tumor-infiltrating immune cell profiles and their change after neoadjuvant chemotherapy predict response and prognosis of breast cancer.

ABSTRACT:

Introduction

Tumor microenvironment immunity is associated with breast cancer outcome. A high lymphocytic infiltration has been associated with response to neoadjuvant chemotherapy, but the contribution to response and prognosis of immune cell subpopulations profiles in both pre-treated and post-treatment residual tumor is still unclear.

Methods

We analyzed pre- and post-treatment tumor-infiltrating immune cells (CD3, CD4, CD8, CD20, CD68, Foxp3) by immunohistochemistry in a series of 121 breast cancer patients homogeneously treated with neoadjuvant chemotherapy. Immune cell profiles were analyzed and correlated with response and survival.

Results

We identified three tumor-infiltrating immune cell profiles, which were able to predict pathological complete response (pC

SUBMITTER: Garcia-Martinez E 

PROVIDER: S-EPMC4303200 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature