Shift in GATA3 functions, and GATA3 mutations, control progression and clinical presentation in breast cancer.

ABSTRACT:

Introduction

GATA binding protein 3 (GATA3) is a regulator of mammary luminal cell differentiation, and an estrogen receptor (ER) associated marker in breast cancer. Tumor suppressor functions of GATA3 have been demonstrated primarily in basal-like breast cancers. Here, we focused on its function in luminal breast cancer, where GATA3 is frequently mutated, and its levels are significantly elevated.

Methods

GATA3 target genes were identified in normal- and luminal cancer- mammary cells by ChIP-seq, followed by examination of the effects of GATA3 expressions and mutations on tumorigenesis-associated genes and processes. Additionally, mutations and expression data of luminal breast cancer patients from The Cancer Genome Atlas were analyzed to characterize genetic signatures ass

SUBMITTER: Cohen H 

PROVIDER: S-EPMC4303202 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature