Outcomes of children exposed in utero to chemotherapy for breast cancer.

ABSTRACT:

Introduction

The incidence of breast cancer diagnosed during pregnancy is expected to increase as more women delay childbearing in the United States. Treatment of cancer in pregnant women requires prudent judgment to balance the benefit to the cancer patient and the risks to the fetus. Prospective data on the outcomes of children exposed to chemotherapy in utero are limited for the breast cancer population.

Methods

Between 1992 and 2010, 81 pregnant patients with breast cancer were treated in a single-arm, institutional review board-approved study with 5-fluorouracil, doxorubicin, and cyclophosphamide (FAC) in the adjuvant or neoadjuvant setting. Labor and delivery records were reviewed for each patient and neonate. In addition, the parents or guardians were surveyed regardi

SUBMITTER: Murthy RK 

PROVIDER: S-EPMC4303207 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature