Differential Effect of Active Smoking on Gene Expression in Male and Female Smokers.

ABSTRACT: Smoking is the second leading cause of preventable death in the United States. Cohort epidemiological studies have demonstrated that women are more vulnerable to cigarette-smoking induced diseases than their male counterparts, however, the molecular basis of these differences has remained unknown. In this study, we explored if there were differences in the gene expression patterns between male and female smokers, and how these patterns might reflect different sex-specific responses to the stress of smoking. Using whole genome microarray gene expression profiling, we found that a substantial number of oxidant related genes were expressed in both male and female smokers, however, smoking-responsive genes did indeed differ greatly between male and female smokers. Gene set enrichment analysis

SUBMITTER: Paul S 

PROVIDER: S-EPMC4303254 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature