Time-varying respiratory system elastance: a physiological model for patients who are spontaneously breathing.

ABSTRACT:

Background

Respiratory mechanics models can aid in optimising patient-specific mechanical ventilation (MV), but the applications are limited to fully sedated MV patients who have little or no spontaneously breathing efforts. This research presents a time-varying elastance (E(drs)) model that can be used in spontaneously breathing patients to determine their respiratory mechanics.

Methods

A time-varying respiratory elastance model is developed with a negative elastic component (E(demand)), to describe the driving pressure generated during a patient initiated breathing cycle. Data from 22 patients who are partially mechanically ventilated using Pressure Support (PS) and Neurally Adjusted Ventilatory Assist (NAVA) are used to investigate the physiology relevance of the time-var

SUBMITTER: Chiew YS 

PROVIDER: S-EPMC4303416 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature