Neurocognitive change in the era of HIV combination antiretroviral therapy: the longitudinal CHARTER study.

ABSTRACT:

Background

Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) can show variable clinical trajectories. Previous longitudinal studies of HAND typically have been brief, did not use adequate normative standards, or were conducted in the context of a clinical trial, thereby limiting our understanding of incident neurocognitive (NC) decline and recovery.

Methods

We investigated the incidence and predictors of NC change over 16-72 (mean, 35) months in 436 HIV-infected participants in the CNS HIV Anti-Retroviral Therapy Effects Research cohort. Comprehensive laboratory, neuromedical, and NC assessments were obtained every 6 months. Published, regression-based norms for NC change were used to generate overall change status (decline vs stable vs improved)

SUBMITTER: Heaton RK 

PROVIDER: S-EPMC4303775 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature