Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.

ABSTRACT: Hypertension is a common disorder and the leading risk factor for cardiovascular disease and premature deaths worldwide. Genome-wide association studies (GWASs) in the European population have identified multiple chromosomal regions associated with blood pressure, and the identified loci altogether explain only a small fraction of the variance for blood pressure. The differences in environmental exposures and genetic background between Chinese and European populations might suggest potential different pathways of blood pressure regulation. To identify novel genetic variants affecting blood pressure variation, we conducted a meta-analysis of GWASs of blood pressure and hypertension in 11 816 subjects followed by replication studies including 69 146 additional individuals. We identified geno

SUBMITTER: Lu X 

PROVIDER: S-EPMC4303798 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature