Association between PLCE1 rs2274223 A > G polymorphism and cancer risk: proof from a meta-analysis.

ABSTRACT: Phospholipase C epsilon 1 (PLCE1) plays an important role in cell growth, differentiation and oncogenesis. An increasing number of individual studies have investigated the association between PLCE1 rs2274223 polymorphism and cancer risk, but the conclusions are inconclusive. To obtain a comprehensive conclusion, we performed a meta-analysis of 22 studies with 13188 cases and 14666 controls. The pooled results indicated that PLCE1 rs2274223 A > G polymorphism was associated with an increased risk of overall cancer (G vs. A: OR = 1.15, 95% CI = 1.06-1.25; GG vs. AA: OR = 1.30, 95% CI = 1.10-1.55; GA vs. AA: OR = 1.18, 95% CI = 1.08-1.30; GG/GA vs. AA: OR = 1.20, 95% CI = 1.08-1.32; GG vs.

Ga/aa

OR = 1.22, 95% CI = 1.04-1.42). The stratification analysis showed the polymorphism was sig

SUBMITTER: Xue W 

PROVIDER: S-EPMC4303865 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature