Next-generation sequencing sheds light on the natural history of hepatitis C infection in patients who fail treatment.

ABSTRACT:

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High rates of sexually transmitted infection and reinfection with hepatitis C virus (HCV) have recently been reported in human immunodeficiency virus (HIV)-infected men who have sex with men and reinfection has also been described in monoinfected injecting drug users. The diagnosis of reinfection has traditionally been based on direct Sanger sequencing of samples pre- and posttreatment, but not on more sensitive deep sequencing techniques. We studied viral quasispecies dynamics in patients who failed standard of care therapy in a high-risk HIV-infected cohort of patients with early HCV infection to determine whether treatment failure was associated with reinfection or recrudescence of preexisting infection. Paired sequences (pre- and posttreatment) were analyzed. The HCV

SUBMITTER: Abdelrahman T 

PROVIDER: S-EPMC4303934 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature