Exhaustive data mining comparison of the effects of low doses of ionizing radiation, formaldehyde and dioxins.

ABSTRACT:

Background

Ionizing radiation in low doses is the ubiquitous environmental factor with harmful stochastic effects. Formaldehyde is one of the most reactive household and industrial pollutants. Dioxins are persistent organic pollutants and most potent synthetic poisons effective even at trace concentrations. Environmental pollutants are capable of altering the expression of a variety of genes. To identify the similarities and differences in the effects of low-dose ionizing radiation, formaldehyde and dioxin on gene expression, we performed the bioinformatic analysis of all available published data.

Results

We found that that in addition to the common p53-, ATM- and MAPK-signaling stress response pathways, genes of cell cycle regulation and proinflammatory cytokines, the studi

SUBMITTER: Moskalev A 

PROVIDER: S-EPMC4303946 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature