Sequence-based model of gap gene regulatory network.

ABSTRACT:

Background

The detailed analysis of transcriptional regulation is crucially important for understanding biological processes. The gap gene network in Drosophila attracts large interest among researches studying mechanisms of transcriptional regulation. It implements the most upstream regulatory layer of the segmentation gene network. The knowledge of molecular mechanisms involved in gap gene regulation is far less complete than that of genetics of the system. Mathematical modeling goes beyond insights gained by genetics and molecular approaches. It allows us to reconstruct wild-type gene expression patterns in silico, infer underlying regulatory mechanism and prove its sufficiency.

Results

We developed a new model that provides a dynamical description of gap gene regulatory

SUBMITTER: Kozlov K 

PROVIDER: S-EPMC4303948 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature