Genetic variation predicts serum lycopene concentrations in a multiethnic population of postmenopausal women.

ABSTRACT:

Background

The consumption and blood concentrations of lycopene are both positively and inversely associated with the risk of several chronic diseases. The inconsistences in lycopene disease association studies may stem from a lack of knowledge about the genetic variation in the synthesis, metabolism, and deposition of transport and binding proteins, which potentially influence serum lycopene concentrations.

Objective

We examined the association between variation across the genome and serum concentrations of lycopene in a multiethnic population.

Methods

Participants included African (n = 914), Hispanic (n = 464), and European (n = 1203) American postmenopausal women from the Women's Health Initiative. We analyzed ∼7 million single nucleotide polymorphisms (SNPs). Line

SUBMITTER: Zubair N 

PROVIDER: S-EPMC4304022 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature