GWAMAR: genome-wide assessment of mutations associated with drug resistance in bacteria.

ABSTRACT:

Background

Development of drug resistance in bacteria causes antibiotic therapies to be less effective and more costly. Moreover, our understanding of the process remains incomplete. One promising approach to improve our understanding of how resistance is being acquired is to use whole-genome comparative approaches for detection of drug resistance-associated mutations.

Results

We present GWAMAR, a tool we have developed for detecting of drug resistance-associated mutations in bacteria through comparative analysis of whole-genome sequences. The pipeline of GWAMAR comprises several steps. First, for a set of closely related bacterial genomes, it employs eCAMBer to identify homologous gene families. Second, based on multiple alignments of the gene families, it identifies mutati

SUBMITTER: Wozniak M 

PROVIDER: S-EPMC4304204 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature