Identification of conserved and polymorphic STRs for personal genomes.

ABSTRACT:

Background

Short tandem repeats (STRs) are abundant in human genomes. Numerous STRs have been shown to be associated with genetic diseases and gene regulatory functions, and have been selected as genetic markers for evolutionary and forensic analyses. High-throughput next generation sequencers have fostered new cutting-edge computing techniques for genome-scale analyses, and cross-genome comparisons have facilitated the efficient identification of polymorphic STR markers for various applications.

Results

An automated and efficient system for detecting human polymorphic STRs at the genome scale is proposed in this study. Assembled contigs from next generation sequencing data were aligned and calibrated according to selected reference sequences. To verify identified polymorphi

SUBMITTER: Chen CM 

PROVIDER: S-EPMC4304208 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature