Association of variants in genes encoding for macrophage-related functions with clinical outcome in patients with locoregional gastric cancer.

ABSTRACT:

Background

Nuclear factor-kappaB (NF-κB) and CCL2/CCR2 chemokine axis play a central role in tumor progression such as stimulation of angiogenesis, acceleration of tumor invasion and migration, and suppression of innate immunosurveillance in the macrophage-related functions. There have been few reports regarding association of the macrophage function-related genes with the clinical outcome in gastric cancer. We hypothesized that variants in genes encoding for NF-κB and CCL2/CCR2 axis may predict prognosis in gastric cancer and tested whether the functional single-nucleotide polymorphisms (SNPs) will be associated with clinical outcome in patients with gastric cancer across two independent groups.

Patients and methods

This study enrolled two cohorts which consisted of 160 Jap

SUBMITTER: Sunakawa Y 

PROVIDER: S-EPMC4304380 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature