A summary of the osteosarcoma banking efforts: a report from the Children's Oncology Group and the QuadW Foundation.

ABSTRACT:

Background

Survival rates of patients with osteosarcoma have remained stagnant over the last thirty years. Better understanding of biology, new therapeutics, and improved biomarkers are needed. The Children's Oncology Group (COG) addressed this need by developing one of the largest osteosarcoma biorepositories ever, containing over 15,000 tumor and tissue samples from over 1,500 patients.

Procedure

The biology study P9851 and the banking study AOST06B1 has enrolled 1,787 patients (as of September, 2013). Clinical information was lacking on 510 patients on P9851, who were not enrolled on a concurrent therapeutic trial. The value of these specimens was diminished. The lack of statistical support available for biology projects slowed the analysis of several critical studies. Th

SUBMITTER: Glover J 

PROVIDER: S-EPMC4304398 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature