Administered paricalcitol dose and survival in hemodialysis patients: a marginal structural model analysis.

ABSTRACT:

Purpose

Several observational studies have indicated that vitamin D receptor activators (VDRA), including paricalcitol, are associated with greater survival in maintenance hemodialysis (MHD) patients. However, patients with higher serum parathyroid hormone, a surrogate of higher death risk, are usually given higher VDRA doses, which can lead to confounding by indication and attenuate the expected survival advantage of high VDRA doses.

Methods

We examined mortality-predictability of low (>1 but <10 µg/week) versus high (≥10 µg/week) dose of administered paricalcitol over time in a contemporary cohort of 15 442 MHD patients (age 64 ± 15 years, 55% men, 44% diabetes, 35% African-Americans) from all DaVita dialysis clinics across the USA (7/2001-6/2006 with survival follow-ups u

SUBMITTER: Miller JE 

PROVIDER: S-EPMC4304639 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature