Ontology highlight
ABSTRACT:
SUBMITTER: Thomas R
PROVIDER: S-EPMC4304668 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Leukemia & lymphoma 20110307 7
Identification of the genomic regions most intimately associated with non-Hodgkin lymphoma (NHL) pathogenesis is confounded by the genetic heterogeneity of human populations. We hypothesize that the restricted genetic variation of purebred dogs, combined with the contrasting architecture of the human and canine karyotypes, will increase the penetrance of fundamental NHL-associated chromosomal aberrations in both species. We surveyed non-random aneuploidy in 150 canine NHL cases, revealing limite ...[more]