Secondary hyperalgesia phenotypes exhibit differences in brain activation during noxious stimulation.

ABSTRACT: Noxious stimulation of the skin with either chemical, electrical or heat stimuli leads to the development of primary hyperalgesia at the site of injury, and to secondary hyperalgesia in normal skin surrounding the injury. Secondary hyperalgesia is inducible in most individuals and is attributed to central neuronal sensitization. Some individuals develop large areas of secondary hyperalgesia (high-sensitization responders), while others develop small areas (low-sensitization responders). The magnitude of each area is reproducible within individuals, and can be regarded as a phenotypic characteristic. To study differences in the propensity to develop central sensitization we examined differences in brain activity and anatomy according to individual phenotypical expression of secondary hypera

SUBMITTER: Asghar MS 

PROVIDER: S-EPMC4304709 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature