Prediction formulas for individual opioid analgesic requirements based on genetic polymorphism analyses.

ABSTRACT:

Background

The analgesic efficacy of opioids is well known to vary widely among individuals, and various factors related to individual differences in opioid sensitivity have been identified. However, a prediction model to calculate appropriate opioid analgesic requirements has not yet been established. The present study sought to construct prediction formulas for individual opioid analgesic requirements based on genetic polymorphisms and clinical data from patients who underwent cosmetic orthognathic surgery and validate the utility of the prediction formulas in patients who underwent major open abdominal surgery.

Methods

To construct the prediction formulas, we performed multiple linear regression analyses using data from subjects who underwent cosmetic orthognathic surgery

SUBMITTER: Yoshida K 

PROVIDER: S-EPMC4304713 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature