Health-related quality of life in children with sickle cell anemia: impact of blood transfusion therapy.

ABSTRACT: The completion of the Multicenter Silent Infarct Transfusion Trial demonstrated that children with pre-existing silent cerebral infarct and sickle cell anemia (SCA) who received regular blood transfusion therapy had a 58% relative risk reduction of infarct recurrence when compared to observation. However, the total benefit of blood transfusion therapy, as assessed by the parents, was not measured against the burden of monthly blood transfusion therapy. In this planned ancillary study, we tested the hypothesis that a patient centered outcome, health-related quality of life (HRQL), would be greater in participants randomly assigned to the blood transfusion therapy group than the observation group. A total of 89% (175 of 196) of the randomly allocated participants had evaluable entry and exit

SUBMITTER: Beverung LM 

PROVIDER: S-EPMC4304929 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature