Early-pregnancy vitamin D deficiency and risk of preterm birth subtypes.

ABSTRACT:

Objective

To estimate the association between maternal 25-hydroxyvitamin D concentrations and risk of preterm birth subtypes.

Methods

We performed a case-cohort study using data and banked samples from patients at a teaching hospital in Pittsburgh, Pennsylvania. Eligible participants were women with a prenatal aneuploidy screening serum sample at or before 20 weeks of gestation who subsequently delivered a singleton, liveborn neonate. Of the 12,861 eligible women, we selected 2,327 at random as well as all remaining preterm birth cases for a total of 1,126 cases. Serum 25-hydroxyvitamin D was measured using liquid chromatography-tandem mass spectrometry. Multivariable log-binomial regression models were used to estimate associations between maternal vitamin D status and pret

SUBMITTER: Bodnar LM 

PROVIDER: S-EPMC4304969 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature