Racial diversity of actionable mutations in non-small cell lung cancer.

ABSTRACT:

Introduction

Lung cancer is the leading cause of cancer-related deaths in the US. The reasons for higher incidence and poorer survival rates among black compared with white lung cancer patients have not been defined. We hypothesized that differential incidence of somatic cancer gene mutations may be a contributing factor. Previous genomic studies of non-small cell lung cancer (NSCLC) have not adequately represented black patients.

Methods

A matrix-assisted laser desorption/ionization and time-of-flight mass spectrometry approach was used to analyze tumor DNA for 214 coding mutations in 26 cancer genes previously identified in NSCLC. The samples included NSCLC from 335 white patients and 137 black patients. For 299 of these, normal matched DNA was available and analyzed.

R

SUBMITTER: Bollig-Fischer A 

PROVIDER: S-EPMC4305026 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature