Immediate rescue designs in pediatric analgesic trials: a systematic review and meta-analysis.

ABSTRACT:

Background

Designing analgesic clinical trials in pediatrics requires a balance between scientific, ethical, and practical concerns. A previous consensus group recommended immediate rescue designs using opioid sparing as a surrogate measure of analgesic efficacy. The authors summarize the performance of rescue analgesic designs in pediatric trials of four commonly used classes of analgesics: opioids, nonsteroidal antiinflammatory drugs, acetaminophen, and local anesthetics.

Methods

MEDLINE, Embase, CINAHL, The Cochrane Library, and Web of science were searched in April 2013. The 85 studies selected were randomized or controlled clinical trials using immediate rescue paradigms in postoperative pain settings. A random-effects meta-analysis was used to synthesize predefined out

SUBMITTER: Kossowsky J 

PROVIDER: S-EPMC4305029 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature